The increasing cases of obesity and type 2 diabetes have worried scientists around the world. Meanwhile, scientists at the University of California-Los Angeles have revealed a big mystery through fat cells. Researchers show how obesity increases the risk of type 2 diabetes and how it could open new treatment avenues.
According to research, obesity disrupts the production of key cellular building blocks called ribosomal factors in the body. Due to the lack of these factors, fat stem cells are unable to form new, functional fat cells. As a result, energy is trapped and fat cells increase in size. This process plays an important role in the development of type 2 diabetes. Dr. Claudio Villanueva, who led the research, said that fat tissue is often thought of as harmful, but it plays an important role in controlling blood sugar levels.
new medicine included obese and sugar-prone rats. The fat cells of these mice were four to five times larger than those of lean mice. Scientists gave the mice a drug called rosiglitazone, which brought their ribosomal factor levels back to normal levels. This helped their fat stem cells create new, smaller and better functioning fat cells. The process not only improved the mice’s metabolism, but also eliminated type 2 diabetes. Although the mice remained obese, their blood sugar levels returned to normal.
future expectations This study, published in Cell Reports, may provide new directions in the treatment of type 2 diabetes and other chronic diseases. Scientists believe that by understanding the role of fat cells, effective treatment of diabetes may be possible in the future.