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Breast Cancer: Breast Cancer It is the most common cancer in women. According to the World Health Organization (WHO), 2.3 million new cases are reported every year. Many women lose their lives because of this. However, a research suggests that genetic models may be used to detect this disease.
breast cancer research
A team of researchers in the US has developed a new genetic model for breast cancer that could help scientists understand why and where cancer spreads.
Professor Eran Andracheck of Michigan State University in the US is researching the E2F5 gene and its role in the development of breast cancer.
What are the results?
Based on results from Andrechak's laboratory, it can be said that destruction of E2F5 alters the regulation of cyclin D1. Cyclin D1 is a protein that has been associated with long-latency metastatic breast tumors.
A study published in the journal 'Oncogene' also revealed that deletion of E2F5 in the memory gland leads to the formation of tumors. As scientists better understand how genes affect breast cancer, they will also learn why cancer metastasizes and where cancer is most likely to spread.
What did the researcher say?
According to Andrechek, their mouse model is different from genetically engineered models. While genetically engineered mouse models can be artificially altered by injection to force cancer cells to travel to organs such as the liver or brain, his lab's newly created mouse model makes this unnecessary.
“We are so excited about this model because it does something that most genetically engineered mouse models have not done before,” Andresek said.
How was the study done?
Andrecheck's laboratory uses genetic models as well as bioinformatics to investigate the mechanisms involved in breast cancer development and progression.
Its research focuses on understanding breast tumor development and uses a variety of methods ranging from animal models to computational analysis of gene expression data. Although breast cancer can occur at any age, most women are in their 60s or 70s when they are first diagnosed with the disease.
Andrechak's research is physiologically relevant, because tumors take several years to develop in mice, meaning that mice are developing breast cancer at a similar age to women.