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Breast Cancer: Breast cancer is the most common type of cancer in women. According to the World Health Organization (WHO), 2.3 million new cases are reported every year. Due to which many women have to lose their lives. However, a research suggests using genetic models to detect the disease.
breast cancer research
A team of US researchers has developed a new genetic model for breast cancer that could help scientists understand why and where cancer spreads.
Professor Iran Andracheck of Michigan State University in the US is researching the E2F5 gene and its role in the development of breast cancer.
What were the results?
Based on results from Andracheck's laboratory, it can be said that destruction of E2F5 alters the regulation of cyclin D1. Cyclin D1 is a protein associated with long-term latency in the development of metastatic breast tumors.
A study published in the journal 'Oncogene' also states that destruction of E2F5 in the mammary gland leads to tumor formation. As scientists better understand how genes affect breast cancer, they will be able to learn more about why cancer metastasizes and where cancer is most likely to spread.
What did the researcher say?
According to Andresek, their mouse model is different from genetically engineered models. While genetically engineered mouse models can be artificially altered by injection to force cancer cells to invade organs such as the liver or brain, his lab's new mouse model makes this unnecessary.
“One of the reasons we are so excited about this model is that it does something that most genetically engineered mouse models have not done before,” Andreycheck said. According to Andracheck, breast cancer often spreads to the lymph nodes, bones or liver.
How was the study conducted?
Andrecheck's laboratory uses genetic models as well as bioinformatics to investigate the mechanisms involved in breast cancer development and progression.
His research focuses on understanding breast tumor development and uses a variety of methods ranging from animal models to computational analysis of gene expression data. Although breast cancer can occur at any age, most women are first diagnosed with the disease in their 60s or 70s.
Andresek's research is physiologically relevant because tumors take approximately years to develop in mice, meaning that mice develop breast cancer at about the same age as women.